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Article

Compartmentalization of neuronal and peripheral serotonin synthesis in Drosophila melanogaster.

Genes, brain, and behavior - 1 Nov 2007

Neckameyer W S, Coleman C M, Eadie S, Goodwin S F

Abstract excerpt

In Drosophila, one enzyme (Drosophila tryptophan-phenylalanine hydroxylase, DTPHu) hydroxylates both tryptophan to yield 5-hydroxytryptophan, the first step in serotonin synthesis, and phenylalanine, to generate tyrosine. Analysis of the sequenced Drosophila genome identified an additional enzyme with extensive homology to mammalian tryptophan hydroxylase (TPH), which we have termed DTRHn. We have shown that...

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Identifiers

PMID: 17376153
DOI: 10.1111/j.1601-183X.2007.00307.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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