Article
Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis.
Ultrasound in medicine & biology - 1 Oct 2003
Narita Masako, Kitagawa Kazuo, Nagai Yoji, Hougaku Hidetaka, Hashimoto Hiroyuki, Sakaguchi Manabu, Yang Xing, Takeshita Tatsuya, Morimoto Kanehisa, Matsumoto Masayasu, Hori Masatsugu
Abstract excerpt
Atherosclerotic diseases are thought to be less frequent in Asians compared with Caucasians. Unlike Caucasians, nearly half of Asians have a functional deficiency in the low Km aldehyde dehydrogenase (ALDH2), a key enzyme in alcohol metabolism, which potentially modifies the prevalence of atherosclerosis. This study examined the associations between ALDH2 genotypes ("typical homo," "hetero" or "atypical homo")...
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