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Article

Germline mutations and polymorphisms in the NFKBIA gene in Hodgkin lymphoma.

International journal of cancer - 10 Sept 2005

Osborne Julie, Lake Annette, Alexander Freda E, Taylor G Malcolm, Jarrett Ruth F

Abstract excerpt

Somatic inactivation of NFKBIA, the gene encoding IkappaBalpha, is a frequent occurrence in the malignant Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL). Impairment of IkappaBalpha function results in deregulated NF-kappaB activity, a characteristic of HRS cells. The molecular basis for familial HL, which accounts for approximately 4% of all HL cases, is unclear. To date, familial HL cases have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15858823
DOI: 10.1002/ijc.21036

Genes

NFKBIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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