Article
The early transcription factor GATA-2 is expressed in classical Hodgkin's lymphoma.
The Journal of pathology - 1 Dec 2004
Schneider Eva-Maria, Torlakovic Emina, Stühler Albert, Diehl Volker, Tesch Hans, Giebel Bernd
Abstract excerpt
Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin's lymphoma (cHL) are thought to be derived from germinal centre B-cells in almost all cases. However, expression profiling has revealed that HRS cells do not show a germinal centre B-cell-like phenotype. Although the nature of this aberrant phenotype and the underlying molecular mechanisms remain largely unknown, it has been reported that the activity of...
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