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Article

Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells.

Cancer research - 15 Oct 2000

Müschen M, Re D, Bräuninger A, Wolf J, Hansmann M L, Diehl V, Küppers R, Rajewsky K

Abstract excerpt

Hodgkin and Reed-Sternberg (H/RS) cells in classical Hodgkin's disease (cHD) are thought to be derived from preapoptotic germinal center B cells. However, little is known about the transforming events rescuing the precursor of the H/RS cells from apoptosis. Given the importance of CD95 (Apo-1/Fas)-mediated apoptosis for negative selection within the germinal center, single micromanipulated H/RS cells from 10...

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PMID: 11059754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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