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Article

Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.

Oncogene - 20 May 1999

Cabannes E, Khan G, Aillet F, Jarrett R F, Hay R T

Abstract excerpt

The NF-kappaB/Rel family of transcription factors regulates a wide variety of genes whose products play a fundamental role in inflammatory and immune responses. The implication of NF-kappaB/Rel proteins and their IkappaB regulatory subunits in the control of cellular growth and oncogenesis, was suggested by the induction of fatal lymphomas in birds by the v-rel oncoprotein, and the rearrangement and amplification...

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Source

Identifiers

PMID: 10340377
DOI: 10.1038/sj.onc.1202893

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Mutations in the IkBa gene in Hodgkin's disease suggest a tumour suppressor role for IkappaBalpha.PMID 10340377Read ↗

Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Sternberg cells.Semantic proximity Read ↗

Clonal Deleterious Mutations in the Iκbα Gene in the Malignant Cells in Hodgkin's LymphomaSemantic proximity Read ↗

Constitutive NF-κB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cellsSemantic proximity Read ↗

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.Semantic proximity Read ↗

Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells.Semantic proximity Read ↗

Nuclear Factor κB–dependent Gene Expression Profiling of Hodgkin's Disease Tumor Cells, Pathogenetic Significance, and Link to Constitutive Signal Transducer and Activator of Transcription 5a ActivitySemantic proximity Read ↗

Mutations of NFKBIA, encoding IkappaB alpha, are a recurrent finding in classical Hodgkin lymphoma but are not a unifying feature of non-EBV-associated cases.Semantic proximity Read ↗

High-level nuclear NF-kappa B and Oct-2 is a common feature of cultured Hodgkin/Reed-Sternberg cellsSemantic proximity Read ↗

IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells.Semantic proximity Read ↗

Somatic mutations within the untranslated regions of rearranged Ig genes in a case of classical Hodgkin's disease as a potential cause for the absence of Ig in the lymphoma cells.Semantic proximity Read ↗

Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma.Semantic proximity Read ↗

Mutation analysis of tumor necrosis factor alpha-induced protein 3 gene in Hodgkin lymphoma.Semantic proximity Read ↗

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