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Article

IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells.

Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2007

Watanabe Mariko, Dewan Md Zahidunnabi, Taira Miyako, Shoda Momoko, Honda Mitsuo, Sata Testutaro, Higashihara Masaaki, Kadin Marshall E, Watanabe Toshiki, Yamamoto Naoki, Umezawa Kazuo, Horie Ryouichi

Abstract excerpt

Constitutive nuclear factor kappaB (NF-kappaB) activation characterizes Hodgkin/Reed-Sternberg (H-RS) cells. Blocking constitutive NF-kappaB has been shown to be a potential strategy to treat Hodgkin lymphoma (HL). Here, for the first time we show that although constitutive NF-kappaB level of H-RS cell lines is very high, topoisomerase inhibitors further enhance NF-kappaB activation through IkappaB kinase...

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PMID: 17310217
DOI: 10.1038/labinvest.3700528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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