Article
Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis.
Journal of bioenergetics and biomembranes - 1 Dec 2016
O'Handley Suzanne F, Thirawatananond Puchong, Kang Lin-Woo, Cunningham Jennifer E, Leyva J Alfonso, Amzel L Mario, Gabelli Sandra B
Abstract excerpt
Mycobacterium tuberculosis represents one of the world's most devastating infectious agents - with one third of the world's population infected and 1.5 million people dying each year from this deadly pathogen. As part of an effort to identify targets for therapeutic intervention, we carried out the kinetic characterization of the product of gene rv1700 of M. tuberculosis. Based on its sequence and its structure,...
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