Article
Functional polymorphisms and transcriptional analysis in the 5' region of the human serotonin receptor 1B gene (HTR1B) and their associations with psychiatric disorders.
BMC psychiatry - 9 Oct 2020
Xia Xi, Ding Mei, Xuan Jin-Feng, Xing Jia-Xin, Yao Jun, Wu Xue, Wang Bao-Jie
Abstract excerpt
BACKGROUND: The 5-hydroxytryptamine 1B receptor (5-HT1B) plays an essential role in the serotonin (5-HT) system and is widely involved in a variety of brain activities. HTR1B is the gene encoding 5-HT1B. Genome-wide association studies have shown that HTR1B polymorphisms are closely related to multiple mental and behavioral disorders; however, the functional mechanisms underlying these associations are unknown....
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