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Article

Primary diffuse large B-cell lymphomas of the central nervous system are targeted by aberrant somatic hypermutation.

Blood - 1 Mar 2004

Montesinos-Rongen Manuel, Van Roost Dirk, Schaller Carlo, Wiestler Otmar D, Deckert Martina

Abstract excerpt

We have addressed whether aberrant ongoing hypermutation can be detected in the proto-oncogenes PIM1, c-MYC, RhoH/TTF, PAX5, and the tumor-suppressor gene CD95 in primary central nervous system lymphomas (PCNSLs) derived from immunocompetent HIV-negative patients. Nine of 10 PCNSLs analyzed harbored somatic mutations in the PIM1, c-MYC, RhoH/TTF, and PAX5 genes, but not in the CD95 gene, with 8 tumors carrying...

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Source

Identifiers

PMID: 14592832
DOI: 10.1182/blood-2003-05-1465

Genes

MYC
PAX5
PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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