Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas.

doi:10.1158/1078-0432.CCR-12-0845

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Article

Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2012

Gonzalez-Aguilar Alberto, Idbaih Ahmed, Boisselier Blandine, Habbita Naïma, Rossetto Marta, Laurenge Alice, Bruno Aurélie, Jouvet Anne, Polivka Marc, Adam Clovis, Figarella-Branger Dominique, Miquel Catherine, Vital Anne, Ghesquières Hervé, Gressin Rémy, Delwail Vincent, Taillandier Luc, Chinot Olivier, Soubeyran Pierre, Gyan Emmanuel, Choquet Sylvain, Houillier Caroline, Soussain Carole, Tanguy Marie-Laure, Marie Yannick, Mokhtari Karima, Hoang-Xuan Khê

Abstract excerpt

PURPOSE: Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance. EXPERIMENTAL DESIGN: We investigated a series of 29 newly diagnosed, HIV-negative, PCNSL patients using high-resolution single-nucleotide polymorphism (SNP) arrays (n = 29) and whole-exome sequencing (n = 4) approaches. Recurrent homozygous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Central Nervous System Neoplasms

Share to Chromosomal Instability

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Share to Lymphoma, Large B-Cell, Diffuse

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Source

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Identifiers

PMID: 22837180
DOI: 10.1158/1078-0432.CCR-12-0845

Genes

MYD88
DOCK5
HDAC9
TOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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