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Article

Evidence for quasispecies distributions in the human hepatitis A virus genome.

Virology - 10 Oct 2003

Sánchez Glòria, Bosch Albert, Gómez-Mariano Gema, Domingo Esteban, Pintó Rosa M

Abstract excerpt

Nucleotide sequence analysis of multiple molecular clones of the hepatitis A virus (HAV), generated by reverse transcription-PCR of two capsid-coding regions, revealed a degree of heterogeneity compatible with a quasispecies structure in three clinical samples. Passage of plaque-purified reference strain HAV pHM175 43c in FRhK-4 cells documented the generation of a mutant distribution of HAV genomes. The mutant...

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Identifiers

PMID: 14592757
DOI: 10.1016/s0042-6822(03)00483-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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