Article
Nuclear colocalization of c-myc protein and hsp70 in cells transfected with human wild-type and mutant c-myc genes.
Experimental cell research - 1 Dec 1992
Henriksson M, Classon M, Axelson H, Klein G, Thyberg J
Abstract excerpt
Using immunofluorescence and electron microscopy we have studied the localization of wild-type and mutant c-myc proteins transiently expressed in CV-1 cells. In agreement with our previous observations, wild-type c-myc protein accumulated in large amorphous globules in the nucleus. All mutant proteins tested accumulated in the nucleus as well, but gave rise to morphologically different inclusion bodies. Many...
Topics
- Animals
- Cell Line
- Cell Nucleus
- Cytoplasm
- Genes, myc
- Heat-Shock Proteins
- Humans
- Microscopy, Electron
- Microscopy, Fluorescence
- Mutation
- Proto-Oncogene Proteins c-myc