Article
Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants.
Genes & development - 1 Aug 1992
Mukherjee B, Morgenbesser S D, DePinho R A
Abstract excerpt
The myc family of cellular oncogenes encodes three highly related nuclear phosphoproteins (c-Myc, N-Myc, and L-Myc) that are believed to function as sequence-specific transcription factors capable of regulating genes important in cellular growth and differentiation. Current evidence indicates tha...
Topics
- Basic-Leucine Zipper Transcription Factors
- Blotting, Northern
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Genes, myc
- Genes, ras
- Mutation
- Plasmids
- Precipitin Tests
- Proto-Oncogene Proteins c-myc
- Transcription Factors