Article
Biphasic effect of Max on Myc cotransformation activity and dependence on amino- and carboxy-terminal Max functions.
Genes & development - 1 Dec 1992
Prendergast G C, Hopewell R, Gorham B J, Ziff E B
Abstract excerpt
In Ras cotransformation assays, Max exhibited a biphasic effect on Myc transformation activity. Cotransfection of low levels of Max expression plasmid stimulated Myc transformation activity, but cotransfection of high levels suppressed it. Mutations in the functionally undefined Max amino- and carboxy-terminal regions outside of the B/HLH/LZ motif partly separated these activities, suggesting various modes of Max...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
- Basic-Leucine Zipper Transcription Factors
- Cell Line
- Cell Transformation, Neoplastic
- Consensus Sequence
- DNA
- DNA-Binding Proteins