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Article

Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jul 1999

Li S H, Cheng A L, Li H, Li X J

Abstract excerpt

Expanded polyglutamine tracts cause huntingtin and other proteins to accumulate and aggregate in neuronal nuclei. Whether the intranuclear aggregation or localization of a polyglutamine protein initiates cellular pathology remains controversial. We established stably transfected pheochromocytoma PC12 cells that express the N-terminal fragment of huntingtin containing 20 (20Q) or 150 (150Q) glutamine residues. The...

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Identifiers

PMID: 10377328
PMCID: PMC6782329

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