Antisense inhibition of the 27 kDa heat shock protein production affects growth rate and cytoskeletal organization in MCF-7 cells.

doi:10.1006/cbir.1996.0025

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Article

Antisense inhibition of the 27 kDa heat shock protein production affects growth rate and cytoskeletal organization in MCF-7 cells.

Cell biology international - 1 Mar 1996

Mairesse N, Horman S, Mosselmans R, Galand P

Abstract excerpt

MCF-7 cells were co-transfected with the human HSP27 antisense cDNA and the neomycin resistance gene, included in the constitutive expression vector pSVL, and the phenotypical changes associated with decreased expression of the HSP27 protein were analysed. Three out of 10 neomycin-resistant clone...

Topics

Actins
Antibody Specificity
Antisense Elements (Genetics)
Base Sequence
Blotting, Western
Breast Neoplasms
Cell Division
Clone Cells
Cytoskeleton
Female
Gentamicins
Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Phenotype

Transfection

Trypsin

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8673069
DOI: 10.1006/cbir.1996.0025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8673069-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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