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Article

Mutation spectra induced by adozelesin in the supF gene of human XP-A fibroblasts.

Archives of pharmacal research - 1 Apr 2010

Lee Se-Young, Pfeifer Gerd P, Lee Chong-Soon

Abstract excerpt

Adozelesin is a synthetic analog of the antitumor antibiotic, CC-1065, which alkylates N3 of adenine in the minor DNA groove in a sequence-specific manner. Here we tested the mutation spectra induced by adozelesin in the supF gene of human XP-A fibroblasts using a shuttle vector assay. Adozelesin primarily induces mutations via an A --> T transversion and a single base insertion. The A --> T transversion (43/59)...

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Share to Antineoplastic Agents, Alkylating
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20422374
DOI: 10.1007/s12272-010-0419-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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