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Article

Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2003

Lim Jin T E, Piazza Gary A, Pamukcu Rifat, Thompson W Joseph, Weinstein I Bernard

Abstract excerpt

In recent studies, we found that sulindac sulfide (SS), exisulind, CP248, and CP461 induce growth inhibition and apoptosis in a series of human prostate cancer cell lines, irrespective of cyclooxygenase expression, p53 mutations, or bcl-2 overexpression. Exisulind also inhibited the growth of the androgen-dependent LNCaP human prostate cancer cell line when grown as a xenograft in nude mice. This study...

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PMID: 14581372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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