Article
Multimodal actions of the phytochemical sulforaphane suppress both AR and AR-V7 in 22Rv1 cells: Advocating a potent pharmaceutical combination against castration-resistant prostate cancer.
Oncology reports - 1 Nov 2017
Khurana Namrata, Kim Hogyoung, Chandra Partha K, Talwar Sudha, Sharma Pankaj, Abdel-Mageed Asim B, Sikka Suresh C, Mondal Debasis
Abstract excerpt
Prostate cancer (PCa) cells expressing full-length androgen receptor (AR-FL) are susceptible to androgen deprivation therapy (ADT). However, outgrowth of castration-resistant prostate cancer (CRPC) can occur due to the expression of constitutively active (ligand-independent) AR splice variants, particularly AR-V7. We previously demonstrated that sulforaphane (SFN), an isothiocyanate phytochemical, can decrease...
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