Article
Cloning and functional analysis of the rhesus macaque ABCG2 gene. Forced expression confers an SP phenotype among hematopoietic stem cell progeny in vivo.
The Journal of biological chemistry - 14 Jan 2005
Ueda Takahiro, Brenner Sebastian, Malech Harry L, Langemeijer Saskia M, Perl Shira, Kirby Martha, Phang Oswald A, Krouse Allen E, Donahue Robert E, Kang Elizabeth M, Tisdale John F
Abstract excerpt
Hematopoietic cells can be highly enriched for repopulating ability based upon the efflux of the fluorescent Hoechst 33342 dye by sorting for SP (side population) cells, a phenotype attributed to expression of ABCG2, a member of the ABC transporter superfamily. Intriguingly, murine studies sugges...
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