Article
Erythroblasts highly express the ABC transporter Bcrp1/ABCG2 but do not show the side population (SP) phenotype.
Immunology letters - 30 Nov 2007
Yamamoto Kazumi, Suzu Shinya, Yoshidomi Yuka, Hiyoshi Masateru, Harada Hideki, Okada Seiji
Abstract excerpt
Stem cells in various somatic tissues including hematopoietic stem cells can be identified by the "side population (SP)" phenotype based on the efflux of Hoechst33342. Knockout and enforced expression experiments show that the expression of the Bcrp1/ABCG2 gene is an important determinant of the SP phenotype. In this study, we showed that erythroblasts also express a large amount of Bcrp1/ABCG2. The level of...
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