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Article

Correlation between pyrazinamide activity and pncA mutations in Mycobacterium tuberculosis isolates in Taiwan.

Antimicrobial agents and chemotherapy - 1 Nov 2003

Huang Tsi-Shu, Lee Susan Shin-Jung, Tu Hui-Zin, Huang Wen-Kuei, Chen Yao-Shen, Huang Chung-Kai, Wann Shue-Ren, Lin Hsi-Hsun, Liu Yung-Ching

Abstract excerpt

A total of 76 clinical Mycobacterium tuberculosis isolates from Taiwan were tested for pyrazinamidase activity, pyrazinamide susceptibility, and pncA mutations. Frequency of resistance to PZA rose with increases in resistance to first-line drugs. Of 17 pyrazinamide-resistant strains, 7 (3 of which had not been previously described) possessed mutations in the pncA gene.

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Identifiers

PMID: 14576145
DOI: 10.1128/AAC.47.11.3672-3673.2003
PMCID: PMC253789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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