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Article

Genetic and phenotypic characterization of pyrazinamide-resistant mycobacterium tuberculosis complex isolates in Japan.

Diagnostic microbiology and infectious disease - 1 Feb 2004

Miyagi Chika, Yamane Nobuhisa, Yogesh Bhusal, Ano Hiromi, Takashima Tetsuya

Abstract excerpt

The pncA gene mutations associated with pyrazinamide (PZA) resistance in Mycobacterium tuberculosis complex were determined in 26 PZA-resistant isolates in Japan. Of the 26 PZA-resistant isolates included, 21 were negative for pyrazinamidase (PZase). Of these, 20 isolates had various pncA mutations, resulting in alteration of primary amino acid sequence. However, 1 PZase-negative isolate did not have any mutation...

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Identifiers

PMID: 14972380
DOI: 10.1016/j.diagmicrobio.2003.09.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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