Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

doi:10.1016/s0962-8479(98)80004-x

Article

Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jan 1997

Hirano K, Takahashi M, Kazumi Y, Fukasawa Y, Abe C

Abstract excerpt

OBJECTIVE: To characterize the correlation of the mutations in the pncA gene encoding pyrazinamidase (PZase) of Mycobacterium tuberculosis to a loss of PZase activity and development of pyrazinamide (PZA) resistance. DESIGN: The association of PZase activity, minimum inhibitory concentrations (MI...

Topics

Amidohydrolases
Drug Resistance, Microbial
Microbial Sensitivity Tests
Mutation
Mycobacterium tuberculosis
Polymerase Chain Reaction
Pyrazinamide

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