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Article

Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis.

Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jan 1997

Hirano K, Takahashi M, Kazumi Y, Fukasawa Y, Abe C

Abstract excerpt

OBJECTIVE: To characterize the correlation of the mutations in the pncA gene encoding pyrazinamidase (PZase) of Mycobacterium tuberculosis to a loss of PZase activity and development of pyrazinamide (PZA) resistance. DESIGN: The association of PZase activity, minimum inhibitory concentrations (MICs), and mutations in the pncA gene of M. tuberculosis isolated in mostly Asian countries was investigated. RESULTS:...

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PMID: 9692180
DOI: 10.1016/s0962-8479(98)80004-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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