Article
BUBR1 deficiency results in abnormal megakaryopoiesis.
Blood - 15 Feb 2004
Wang Qi, Liu Tongyi, Fang Yuqiang, Xie Suqing, Huang Xuan, Mahmood Radma, Ramaswamy Gita, Sakamoto Kathleen M, Darzynkiewicz Zbigniew, Xu Ming, Dai Wei
Abstract excerpt
The physiologic function of BUBR1, a key component of the spindle checkpoint, was examined by generating BUBR1-mutant mice. BUBR1(-/-) embryos failed to survive beyond day 8.5 in utero as a result of extensive apoptosis. Whereas BUBR1(+/-) blastocysts grew relatively normally in vitro, BUBR1(-/-)...
Topics
- Animals
- Bone Marrow
- Cell Cycle Proteins
- Cells, Cultured
- Erythropoiesis
- Female
- Genotype
- Hematopoiesis, Extramedullary
- Hematopoietic Stem Cells
- Megakaryocytes
- Mice
- Mice, Knockout
- Platelet Count
- Pregnancy
- Protein Kinases
- Protein Serine-Threonine Kinases
- Splenomegaly