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Article

Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence.

Journal of hematology & oncology - 4 Feb 2016

Park Sung-Hyun, Xie Steve, Rao Chinthalapally V, Dai Wei

Abstract excerpt

BACKGROUND: Spindle assembly checkpoint components BubR1 and Sgo1 play a key role in the maintenance of chromosomal instability during cell division. These proteins function to block the anaphase entry until all condensed chromosomes have been attached by the microtubules emanating from both spindle poles. Haplo-insufficiency of either BubR1 or SGO1 results in enhanced chromosomal instability and tumor...

Topics

Animals
Blotting, Western
Cell Cycle Proteins
Cell Proliferation
Cells, Cultured
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p21
Embryo, Mammalian
Fibroblasts
Genotype
Haploinsufficiency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Knockout

Protein Serine-Threonine Kinases

beta-Galactosidase

Source

Open in PubMed Open full text

Identifiers

PMID: 26847209
DOI: 10.1186/s13045-016-0238-5
PMCID: PMC4743409

Genes

SGO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26847209-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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