Article
Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice.
Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2009
Leland Shawn, Nagarajan Prabakaran, Polyzos Aris, Thomas Sharon, Samaan George, Donnell Robert, Marchetti Francesco, Venkatachalam Sundaresan
Abstract excerpt
Aneuploidy, the most common chromosomal abnormality at birth and the main ascertained cause of pregnancy loss in humans, originates primarily from chromosome segregation errors during oogenesis. Here, we report that heterozygosity for a mutation in the mitotic checkpoint kinase gene, Bub1, induce...
Topics
- Aneuploidy
- Animals
- Centromere
- Female
- Fertility
- Heterozygote
- Litter Size
- Male
- Maternal Age
- Meiosis
- Mice
- Mutation
- Oocytes
- Protein Serine-Threonine Kinases
- RNA, Messenger