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Article

Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2009

Leland Shawn, Nagarajan Prabakaran, Polyzos Aris, Thomas Sharon, Samaan George, Donnell Robert, Marchetti Francesco, Venkatachalam Sundaresan

Abstract excerpt

Aneuploidy, the most common chromosomal abnormality at birth and the main ascertained cause of pregnancy loss in humans, originates primarily from chromosome segregation errors during oogenesis. Here, we report that heterozygosity for a mutation in the mitotic checkpoint kinase gene, Bub1, induces aneuploidy in female germ cells of mice and that the effect increases with advancing maternal age. Analysis of Bub1...

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Identifiers

PMID: 19617567
DOI: 10.1073/pnas.0903075106
PMCID: PMC2722367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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