Article
A single nucleotide primer extension assay to detect the APC I1307K gene variant.
The Journal of molecular diagnostics : JMD - 1 Nov 2003
Murphy Kathleen M, Geiger Tanya, Hafez Michael J, Eshleman James R, Griffin Constance A, Berg Karin D
Abstract excerpt
Adenomatous polyposis coli (APC) is a tumor suppressor gene important in colorectal tumorigenesis. A genetic variant of APC, I1307K, results from a T-to-A transversion at nucleotide 3920 which converts the wild-type sequence to a homopolymer tract (A(8)). The I1307K alteration is not itself oncogenic, but creates a hypermutable region (A(8)) that is prone to frame-shift mutations. The APC I1307K variant occurs in...
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