Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

One step direct detection of recurrent mutations in the breast cancer susceptibility gene, BRCA1.

International journal of oncology - 1 Jun 1998

Richter S, Seth A

Abstract excerpt

Germ-line mutations of the BRCA1 gene have been linked to 85% of hereditary breast and ovarian cancers. More than one hundred mutations have been reported, including several which are over represented within the Ashkenazi Jewish (185delAG) and Irish families (1294del40). These recurrent mutations are cost-effective targets for presymptomatic screening of cancer susceptibility. Most current techniques such as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Breast Neoplasms
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to BRCA1 gene

Share to Gene Deletion

Share to Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 9592184
DOI: 10.3892/ijo.12.6.1263

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

One step direct detection of recurrent mutations in the breast cancer susceptibility gene, BRCA1.PMID 9592184Read ↗

Convenient, nonradioactive, heteroduplex-based methods for identifying recurrent mutations in the BRCA1 and BRCA2 genes.Semantic proximity Read ↗

Direct detection of mutations in the breast and ovarian cancer susceptibility gene BRCA1 by PCR-mediated site-directed mutagenesis.Semantic proximity Read ↗

A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. Implications for presymptomatic testing and screening.Semantic proximity Read ↗

Single-step capture and sequencing of natural DNA for detection of BRCA1 mutations.Semantic proximity Read ↗

A rapid and sensitive approach to mutation detection using real-time polymerase chain reaction and melting curve analyses, using BRCA1 as an example.Semantic proximity Read ↗

A rapid fluorescent multiplexed-PCR analysis (FMPA) for founder mutations in the BRCA1 and BRCA2 genes.Semantic proximity Read ↗

A single nucleotide primer extension assay to detect the APC I1307K gene variant.Semantic proximity Read ↗

Molecular analysis of the eighteen most frequent mutations in the BRCA1 gene in 63 Chilean breast cancer families.Semantic proximity Read ↗

A characterization of genetic variants in BRCA1 intron 8 identifies a mutation and a polymorphism.Semantic proximity Read ↗

BRCA1 mutation screening using restriction endonuclease fingerprinting-single-strand conformation polymorphism in an automated capillary electrophoresis system.Semantic proximity Read ↗

Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site.Semantic proximity Read ↗

Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.