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Article

Genotyping by mass spectrometric analysis of short DNA fragments.

Nature biotechnology - 1 Dec 1998

Laken S J, Jackson P E, Kinzler K W, Vogelstein B, Strickland P T, Groopman J D, Friesen M D

Abstract excerpt

A method has been developed to produce small DNA fragments from PCR products for analysis of defined DNA variations by mass spectrometry. The genomic region to be analyzed is PCR-amplified with primers containing a sequence for the type IIS restriction endonuclease Bpml. Bpml digestion of the resultant PCR products yields fragments as small as seven bases, which are then analyzed by electrospray ionization mass...

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PMID: 9853618
DOI: 10.1038/4333

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