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Article

Limitations of allotopic expression of mitochondrial genes in mammalian cells.

Genetics - 1 Oct 2003

Oca-Cossio Jose, Kenyon Lesley, Hao Huiling, Moraes Carlos T

Abstract excerpt

The possibility of expressing mitochondrial DNA-coded genes in the nuclear-cytoplasmic compartment provides an attractive system for genetic treatment of mitochondrial disorders associated with mitochondrial DNA mutations. In theory, by recoding mitochondrial genes to adapt them to the universal genetic code and by adding a DNA sequence coding for a mitochondrial-targeting sequence, one could achieve correct...

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PMID: 14573482
DOI: 10.1093/genetics/165.2.707
PMCID: PMC1462783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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