Article
[mRNA localization to the mitochondrial surface: a tool to treat retinal pathologies due to mitochondrial DNA mutations].
Journal de la Societe de biologie - 1 Jan 2007
Bonnet Crystel, Kaltimbacher Valérie, Ellouze Sami, Forster Valérie, Sahel José-Alain, Corral-Debrinski Marisol
Abstract excerpt
mRNA subcellular distribution and translational control are key player mechanisms for development, cellular differentiation and synaptic plasticity. mRNA localization is also implicated in mitochondria biogenesis. Two sequences within the transcripts are involved in their mitochondrial localization: the region coding for the mitochondrial targeting sequence (MTS) and the 3'UTR. Therefore, we decided to use mRNA...
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