Article
Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?
Nucleic acids research - 1 Jan 2011
Perales-Clemente Ester, Fernández-Silva Patricio, Acín-Pérez Rebeca, Pérez-Martos Acisclo, Enríquez Jose Antonio
Abstract excerpt
Mitochondrial-DNA diseases have no effective treatments. Allotopic expression-synthesis of a wild-type version of the mutated protein in the nuclear-cytosolic compartment and its importation into mitochondria-has been proposed as a gene-therapy approach. Allotopic expression has been successfully demonstrated in yeast, but in mammalian mitochondria results are contradictory. The evidence available is based on...
Topics
- Animals
- Cell Line
- DNA, Mitochondrial
- Gene Expression
- Genes, Mitochondrial
- Humans
- Mice
- Mitochondria
- Mitochondrial Membranes
- Mitochondrial Proteins
- Mutation
- NADH Dehydrogenase
- NIH 3T3 Cells
- Protein Transport