Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?

Nucleic acids research - 1 Jan 2011

Perales-Clemente Ester, Fernández-Silva Patricio, Acín-Pérez Rebeca, Pérez-Martos Acisclo, Enríquez Jose Antonio

Abstract excerpt

Mitochondrial-DNA diseases have no effective treatments. Allotopic expression-synthesis of a wild-type version of the mutated protein in the nuclear-cytosolic compartment and its importation into mitochondria-has been proposed as a gene-therapy approach. Allotopic expression has been successfully demonstrated in yeast, but in mammalian mitochondria results are contradictory. The evidence available is based on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Mitochondrial
Share to Genes, Mitochondrial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitochondria

Share to Mitochondrial Membranes

Share to Mitochondrial Proteins

Share to NADH Dehydrogenase

Share to NIH 3T3 Cells

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 20823090
DOI: 10.1093/nar/gkq769
PMCID: PMC3017613

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allotopic expression of mitochondrial-encoded genes in mammals: achieved goal, undemonstrated mechanism or impossible task?PMID 20823090Read ↗

Limitations of allotopic expression of mitochondrial genes in mammalian cells.Semantic proximity Read ↗

Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus.Semantic proximity Read ↗

Allotopic mRNA localization to the mitochondrial surface rescues respiratory chain defects in fibroblasts harboring mitochondrial DNA mutations affecting complex I or v subunits.Semantic proximity Read ↗

What limits the allotopic expression of nucleus-encoded mitochondrial genes? The case of the chimeric Cox3 and Atp6 genes.Semantic proximity Read ↗

Factors that might affect the allotopic replacement of a damaged mitochondrial DNA-encoded protein.Semantic proximity Read ↗

Optimized Mitochondrial Targeting of Proteins Encoded by Modified mRNAs Rescues Cells Harboring Mutations in mtATP6.Semantic proximity Read ↗

Progress and prospects: gene therapy for mitochondrial DNA disease.Semantic proximity Read ↗

A new set of mutations in the second transmembrane helix of the Cox2p-W56R substantially improves its allotopic expression in Saccharomyces cerevisiae.Semantic proximity Read ↗

Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes.Semantic proximity Read ↗

Mitochondrial medicine: to a new era of gene therapy for mitochondrial DNA mutations.Semantic proximity Read ↗

Gene Therapy Tools for Diseases Caused by Mutations of the Mitochondrial Genome.Semantic proximity Read ↗

A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.