Article
Gene therapy of mitochondrial DNA mutations: a brief, biased history of allotopic expression in mammalian cells.
Seminars in neurology - 1 Sept 2001
Zullo S J
Abstract excerpt
Successful treatment of mitochondrial DNA (mtDNA) mutations might be possible by construction of mtDNA-encoded protein genes so that they can be inserted into the nuclear genome and the protein expressed in the mitochondria (allotopic expression). This technique would require individual assembly of all 13 mtDNA-encoded protein genes with an aminoterminal leader peptide that directs the cytoplasmic translated...
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