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What limits the allotopic expression of nucleus-encoded mitochondrial genes? The case of the chimeric Cox3 and Atp6 genes.

Mitochondrion - 1 Jan 2011

Figueroa-Martínez Francisco, Vázquez-Acevedo Miriam, Cortés-Hernández Paulina, García-Trejo José J, Davidson Edgar, King Michael P, González-Halphen Diego

Abstract excerpt

Allotopic expression is potentially a gene therapy for mtDNA-related diseases. Some OXPHOS proteins like ATP6 (subunit a of complex V) and COX3 (subunit III of complex IV) that are typically mtDNA-encoded, are naturally nucleus-encoded in the alga Chlamydomonas reinhardtii. The mitochondrial proteins whose genes have been relocated to the nucleus exhibit long mitochondrial targeting sequences ranging from 100 to...

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Identifiers

PMID: 20854934
DOI: 10.1016/j.mito.2010.09.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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