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Article

Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes.

Redox biology - 1 Feb 2020

Lewis Caitlin J, Dixit Bhavna, Batiuk Elizabeth, Hall Carter J, O'Connor Matthew S, Boominathan Amutha

Abstract excerpt

Mutations in mitochondrial DNA can be inherited or occur de novo leading to several debilitating myopathies with no curative option and few or no effective treatments. Allotopic expression of recoded mitochondrial genes from the nucleus has potential as a gene therapy strategy for such conditions, however progress in this field has been hampered by technical challenges. Here we employed codon optimization as a...

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Identifiers

PMID: 31981894
DOI: 10.1016/j.redox.2020.101429
PMCID: PMC6976934

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