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Article

Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila.

Genetics - 1 Oct 2003

Chao Anna T, Dierick Herman A, Addy Tracie M, Bejsovec Amy

Abstract excerpt

In a screen for suppressors of the Drosophila wingless(PE4) nonsense allele, we isolated mutations in the two components that form eukaryotic release factor. eRF1 and eRF3 comprise the translation termination complex that recognizes stop codons and catalyzes the release of nascent polypeptide chains from ribosomes. Mutations disrupting the Drosophila eRF1 and eRF3 show a strong maternal-effect nonsense...

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Identifiers

PMID: 14573473
DOI: 10.1093/genetics/165.2.601
PMCID: PMC1462801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila.PMID 14573473Read ↗

Terminating eukaryote translation: domain 1 of release factor eRF1 functions in stop codon recognition.Semantic proximity Read ↗

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N-terminal extension of Saccharomyces cerevisiae translation termination factor eRF3 influences the suppression efficiency of sup35 mutations.Semantic proximity Read ↗

Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.Semantic proximity Read ↗

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