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Article

Strong diversifying selection on domains of the Plasmodium falciparum apical membrane antigen 1 gene.

Genetics - 1 Aug 2001

Polley S D, Conway D J

Abstract excerpt

The surface-accessible ectodomain region of the Plasmodium falciparum apical membrane antigen 1 (AMA1) is a malaria vaccine candidate. The amino acid sequence may be under selection from naturally acquired immune responses, and previous analyses with a small number of allele sequences indicate a non-neutral pattern of nucleotide variation. To investigate whether there is selection to maintain polymorphism within...

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Identifiers

PMID: 11514442
DOI: 10.1093/genetics/158.4.1505
PMCID: PMC1461755

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