Role of the GH/IGF-I axis in the growth retardation of weaver mice.

doi:10.1007/s12020-007-9003-4

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Article

Role of the GH/IGF-I axis in the growth retardation of weaver mice.

Endocrine - 1 Oct 2007

Yao Weiguo, Bethin Kathleen, Yang Xianlin, Zhong Jin, Lee Wei-Hua

Abstract excerpt

IGF-I is a well-established anabolic growth factor essential for growth and development. Although the role of the GH/IGF-I axis is established for normal postnatal growth, its functional state in neurodegenerative diseases is not fully characterized. The weaver mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides an opportunity to investigate the function of IGF-I in...

Topics

Animals
Body Weight
Disease Models, Animal
Eating
Female
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Gene Expression Regulation
Growth Disorders
Growth Hormone
Insulin
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Neurologic Mutants

Mutation

Neurodegenerative Diseases

Phosphorylation

STAT5 Transcription Factor

Source

Open in PubMed

Identifiers

PMID: 18040896
DOI: 10.1007/s12020-007-9003-4

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