Article
Expression of calcium channel alpha1A mRNA and protein in the leaner mouse (tgla/tgla) cerebellum.
Brain research. Molecular brain research - 15 Aug 1998
Lau F C, Abbott L C, Rhyu I J, Kim D S, Chin H
Abstract excerpt
Homozygous leaner mice carry an autosomal recessive mutation in the Ca2+ channel subunit gene, alpha1A, causing them to exhibit severe ataxia, petit-mal-like epilepsy and a myoclonus-like movement disorder. Expression of alpha1A mRNA in cerebella from 20-day-old homozygous leaner mice was compare...
Topics
- Animals
- Autoradiography
- Calcium Channels
- Cerebellum
- Female
- Genes, Recessive
- Image Processing, Computer-Assisted
- Immunohistochemistry
- In Situ Hybridization
- Male
- Mice
- Mice, Neurologic Mutants
- Mutation
- Purkinje Cells
- RNA, Messenger