Article
High growth reassortant influenza vaccine viruses: new approaches to their control.
Biologicals : journal of the International Association of Biological Standardization - 1 Sept 1992
Robertson J S, Nicolson C, Newman R, Major D, Dunleavy U, Wood J M
Abstract excerpt
When a new strain of an influenza virus is required to be incorporated into influenza vaccine, attempts are made to recombine such strains with laboratory adapted viruses, which will grow to high titre in order to improve the yield of the vaccine strain. It is important that such high growth reassortant vaccine strains are not contaminated with genes coding for the antigenic determinants of the high growth...
Topics
- Antigens, Viral
- Base Sequence
- DNA, Viral
- Humans
- Influenza A virus
- Influenza B virus
- Influenza Vaccines
- Molecular Sequence Data
- Oligonucleotide Probes
- Phenotype
- Polymerase Chain Reaction