Article
The study of gene-environment interactions that influence thrombosis and fibrinolysis. Genetic variation at the loci for factor VII and plasminogen activator inhibitor-1.
Archives of pathology & laboratory medicine - 1 Dec 1992
Humphries S E, Lane A, Dawson S, Green F R
Abstract excerpt
We describe studies on variation in the genes coding for factor VII (FVII) and plasminogen activator inhibitor-1 (PAI-1) that influence levels of these proteins in the blood. For FVII, we have identified a genetic polymorphism that results in the substitution of arginine at residue 353 to glutamine. The frequency of the glutamine allele is approximately 0.1 in samples of individuals from the United Kingdom (n =...
Topics
- Arginine
- Base Sequence
- Factor VII
- Female
- Fibrinolysis
- Genetic Variation
- Glutamine
- Humans
- Lipids
- Male
- Molecular Sequence Data