Article
Low plasma levels of factor VIIc and antigen are more strongly associated with the 10 base pair promoter (-323) insertion than the glutamine 353 variant.
Thrombosis and haemostasis - 1 Apr 1996
Humphries S, Temple A, Lane A, Green F, Cooper J, Miller G
Abstract excerpt
In a group of 705 healthy middle-aged men, we have examined the relationship between plasma levels of Factor VII (FVII) c and Factor VII antigen (FVIIag) and two polymorphisms in the FVII gene. One polymorphism alters arginine at position 353 to glutamine (R/Q), and the other is the result of a 1...
Topics
- Antigens
- Base Composition
- Base Sequence
- DNA Transposable Elements
- Factor VII
- Genetic Variation
- Glutamine
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Reference Values