Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis.

Article

Gene-environment interaction in the determination of levels of haemostatic variables involved in thrombosis and fibrinolysis.

Thrombosis and haemostasis - 1 Jul 1997

Humphries S E, Panahloo A, Montgomery H E, Green F, Yudkin J

Abstract excerpt

Functional sequence changes in the promoter of a gene may have a direct effect on the rate of transcription and thus on cellular or plasma levels of the protein. For both the beta fibrinogen gene and the plasminogen activator inhibitor-1 (PAI-1) gene such functional variations have been described...

Topics

Chromosome Mapping
Environment
Fibrinogen
Fibrinolysis
Genetic Variation
Hemostasis
Humans
Myocardial Ischemia
Thrombosis

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