The contribution of genetic and environmental factors to changes in total and γ' fibrinogen over 5 years.

doi:10.1016/j.thromres.2015.01.015

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Article

The contribution of genetic and environmental factors to changes in total and γ' fibrinogen over 5 years.

Thrombosis research - 1 Apr 2015

Jobse Ané, Pieters Marlien, Nienaber-Rousseau Cornelie, Boshuizen Hendriek, Hoekstra Tiny, de Maat Moniek P M

Abstract excerpt

INTRODUCTION: Increased fibrinogen is associated with cardiovascular disease risk. It is, however, not known to what extend environmental and genetic factors and/or their interaction influence changes in total and γ' fibrinogen over time. We aimed to determine how variation within the fibrinogen gene as well as environmental factors influence the change in total and γ' fibrinogen over time, and also whether...

Topics

Adult
Cross-Sectional Studies
Environmental Exposure
Female
Fibrinogen
Genotype
Humans
Male
Middle Aged
Prospective Studies
Risk Factors

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Open in PubMed

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PMID: 25613928
DOI: 10.1016/j.thromres.2015.01.015

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