Article
Factor VII gene polymorphism, factor VII levels, and prevalent cardiovascular disease: the Framingham Heart Study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2000
Feng D, Tofler G H, Larson M G, O'Donnell C J, Lipinska I, Schmitz C, Sutherland P A, Johnstone M T, Muller J E, D'Agostino R B, Levy D, Lindpaintner K
Abstract excerpt
Elevated factor VII levels have been associated with increased cardiovascular risk in some studies. The arginine/glutamine (Arg/Gln) polymorphism of the factor VII gene has been previously shown to modify factor VII levels. However, the presence of a gene/environment interaction on factor VII levels or a link with cardiovascular disease (CVD) remains uncertain. We studied subjects from the Framingham Heart Study...
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