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Article

Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function.

Proceedings of the National Academy of Sciences of the United States of America - 14 Aug 2001

Condorelli G, Roncarati R, Ross J, Pisani A, Stassi G, Todaro M, Trocha S, Drusco A, Gu Y, Russo M A, Frati G, Jones S P, Lefer D J, Napoli C, Croce C M

Abstract excerpt

Up-regulation of proapoptotic genes has been reported in heart failure and myocardial infarction. To determine whether caspase genes can affect cardiac function, a transgenic mouse was generated. Cardiac tissue-specific overexpression of the proapoptotic gene Caspase3 was induced by using the rat promoter of alpha-myosin heavy chain, a model that may represent a unique tool for investigating new molecules and...

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Identifiers

PMID: 11493678
DOI: 10.1073/pnas.161120198
PMCID: PMC55563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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