DNA Repair: a Double-Edged Sword

Abstract excerpt

It has been estimated that there is a 90 % overlap between mutagenicity and carcinogenicity of environmental chemicals (1) and that environmental exposure to carcinogens contributes to the development of more than 80 % of human cancers (2). Cancer is also considered to be a genetic disease because genetic alterations at either chromosomal or gene levels have been iden-tified in most cancers. In multistep...

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