Mismatch repair, somatic mutations, and the origins of cancer.

Abstract excerpt

This paper outlines the basic properties of a newly recognized pathway that should enable somatic cells to generate double-stranded mutations in the complete absence of cell proliferation. Recognition of the existence of this pathway provides us with the basis for a better understanding of a number of important biological phenomena and, in particular, may help us to understand the origins of cancers in unselected...

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