Mismatch repair, somatic mutations, and the origins of cancer.

Article

Mismatch repair, somatic mutations, and the origins of cancer.

Cancer research - 1 Dec 1995

MacPhee D G

Abstract excerpt

This paper outlines the basic properties of a newly recognized pathway that should enable somatic cells to generate double-stranded mutations in the complete absence of cell proliferation. Recognition of the existence of this pathway provides us with the basis for a better understanding of a numb...

Topics

Cell Division
DNA Repair
DNA Replication
DNA, Bacterial
Escherichia coli
Humans
Interphase
Mutation
Neoplasms
Phenotype
Time Factors

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.